Cyanomethylative cyclization of unactivated alkenes with nitriles for the synthesis of cyano-containing ring-fused quinazolin-4(3H)-ones.
In: New Journal of Chemistry, Jg. 46 (2022-01-21), Heft 3, S. 1347-1352
academicJournal
Zugriff:
The synthesis of cyano-containing ring-fused quinazolin-4(3H)-one derivatives was developed under metal-free conditions. This synthesis involves radical C(sp 3 )–H functionalization of alkyl nitriles, and cascade radical addition/cyclization with N-alkylated quinazolinones to deliver cyanoalkylated pyrrolo- and piperidino-quinazolin-4(3H)-ones in moderate to excellent yields. Moreover, a derivative of the natural product leucomidine C was synthesized conveniently using the current protocol. [ABSTRACT FROM AUTHOR]
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Titel: |
Cyanomethylative cyclization of unactivated alkenes with nitriles for the synthesis of cyano-containing ring-fused quinazolin-4(3H)-ones.
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Autor/in / Beteiligte Person: | Liu, Han ; Yang, Zixian ; Huang, Gao ; Yu, Jin-Tao ; Pan, Changduo |
Zeitschrift: | New Journal of Chemistry, Jg. 46 (2022-01-21), Heft 3, S. 1347-1352 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1144-0546 (print) |
DOI: | 10.1039/d1nj05001j |
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