Cytokine and Chemokine Receptor Patterns of Human Malignant Melanoma Cell Lines.
In: International Journal of Molecular Sciences, Jg. 23 (2022-03-01), Heft 5, S. 2644-2644
Online
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Zugriff:
Cytokine and chemokine receptors can promote tumor progression, invasion, and metastasis development by inducing different intracellular signaling pathways. The aim of this study was to determine the cytokine and chemokine receptor gene expression patterns in human melanoma cell lines. We found a large set of cytokine and chemokine receptor genes that were significantly differentially expressed between melanoma cell lines that originated from different subtypes of primary melanomas as well as cell lines that originated from melanoma metastases. The relative expressions of two receptor genes (CCR2 and TNFRSF11B) were positively correlated with the invasive potential of the cell lines, whereas a negative correlation was observed for the TNFRSF14 gene expression. We also found a small set of receptor genes that exhibited a significantly decreased expression in association with a BRAF V600E mutation. Based on our results, we assume that the analyzed cytokine and chemokine receptor collection may provide potential to distinguish the different subtypes of melanomas, helping us to understand the biological behavior of BRAF V600E -mutated melanoma cells. [ABSTRACT FROM AUTHOR]
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Titel: |
Cytokine and Chemokine Receptor Patterns of Human Malignant Melanoma Cell Lines.
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Autor/in / Beteiligte Person: | Koroknai, Viktoria ; Szász, István ; Jámbor, Krisztina ; Balázs, Margit |
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Zeitschrift: | International Journal of Molecular Sciences, Jg. 23 (2022-03-01), Heft 5, S. 2644-2644 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1661-6596 (print) |
DOI: | 10.3390/ijms23052644 |
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