Therapeutic Efficacy of 177 Lu-Labeled A20FMDV2 Peptides Targeting α ν β 6.
In: Pharmaceuticals (14248247), Jg. 15 (2022-02-01), Heft 2, S. 229-229
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Zugriff:
Integrin α ν β 6 promotes migration and invasion of cancer cells, and its overexpression often correlates with poor survival. Therefore, targeting α ν β 6 with radioactive peptides would be beneficial for cancer imaging and therapy. Previous studies have successfully developed radiotracers based on the peptide A20FMDV2 that showed good binding specificity for α ν β 6 . However, one concern of these α ν β 6 integrin-targeting probes is that their rapid blood clearance and low tumor uptake would preclude them from being used for therapeutic purposes. In this study, albumin binders were used to increase tumor uptake for therapeutic applications while the non-albumin peptide was evaluated as a potential positron emission tomography (PET) imaging agent. All peptides used the DOTA chelator for radiolabeling with either 68 Ga for imaging or 177 Lu for therapy. PET imaging with [ 68 Ga]Ga-DOTA-(PEG28) 2 -A20FMDV2 revealed specific tumor uptake in α ν β 6 -positive tumors. Albumin-binding peptides EB-DOTA-(PEG28) 2 -A20FMDV2 and IBA-DOTA-(PEG28) 2 -A20FMDV2 were radiolabeled with 177 Lu. Biodistribution studies in normal mice showed longer blood circulation times for the albumin binding peptides compared to the non-albumin peptide. Therapy studies in mice demonstrated that both 177 Lu-labeled albumin binding peptides resulted in significant tumor growth inhibition. We believe these are the first studies to demonstrate the therapeutic efficacy of a radiolabeled peptide targeting an α ν β 6 -positive tumor. [ABSTRACT FROM AUTHOR]
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Titel: |
Therapeutic Efficacy of 177 Lu-Labeled A20FMDV2 Peptides Targeting α ν β 6.
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Autor/in / Beteiligte Person: | Huynh, Truc Thao ; Sreekumar, Sreeja ; Mpoy, Cedric ; Rogers, Buck Edward |
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Zeitschrift: | Pharmaceuticals (14248247), Jg. 15 (2022-02-01), Heft 2, S. 229-229 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1424-8247 (print) |
DOI: | 10.3390/ph15020229 |
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