Growth hormone does not affect albumin synthesis in the critically ill.
In: Intensive Care Medicine, Jg. 27 (2001-05-01), Heft 5, S. 836-843
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Zugriff:
Objective: To study the effect of growth hormone (GH) on albumin synthesis in critically ill patients. Design: Prospective randomized controlled study. Setting: Two intensive care units, university hospital and county hospital, respectively. Patients: Twenty-two critically ill patients in the intensive care unit. Interventions: Albumin synthesis was measured twice in each patient, with a 5-day interval. The patients in the control group (n = 11) received standard intensive care unit (ICU) treatment between measurements, whereas those in the GH group (n = 11) also received 0.3 U/kg daily of human recombinant GH. Measurements and Results: Albumin synthesis was measured by labeling with L-[2H5]phenylalanine. In the control group, the fractional synthesis rate (FSR) of albumin was 16.3+/-4.1%/day (mean and SD) in the first measurement and 15.7+/-4.2%/day 5 days later (NS), whereas in the GH group the corresponding values were 17.0+/-4.7%/day and 16.7+/-5.5%/day (NS). The calculated absolute synthesis rates of albumin, based on FSR and intravascular albumin mass, also showed no effect of GH. Conclusion: Albumin synthesis rates were consistently higher in the two groups of critically ill patients than previously reported values in healthy subjects. However, GH treatment for 5 days neither stimulated nor inhibited albumin synthesis rates in these critically ill patients. [ABSTRACT FROM AUTHOR]
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Titel: |
Growth hormone does not affect albumin synthesis in the critically ill.
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Autor/in / Beteiligte Person: | Barle, Hans ; Gamrin, Lena ; Essén, Pia ; McNurlan, Margaret A. ; Garlick, Peter J. ; Wernerman, Jan ; Barle, H ; Gamrin, L ; Essén, P ; McNurlan, M A ; Garlick, P J ; Wernerman, J |
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Zeitschrift: | Intensive Care Medicine, Jg. 27 (2001-05-01), Heft 5, S. 836-843 |
Veröffentlichung: | 2001 |
Medientyp: | academicJournal |
ISSN: | 0342-4642 (print) |
DOI: | 10.1007/s001340100914 |
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