乳腺癌化疗患者外周静脉置入中心静脉导管置管感染的 危险因素分析及其生活质量调查. (Chinese)

Objective: To analyze the risk factors of peripherally inserted central catheter (PICC) catheterization infection in patients with breast cancer undergoing chemotherapy, and to observe their quality of life. Methods: 198 patients with breast cancer who were admitted to our hospital from January 2019 to October 2020 were selected. The general data of all patients were collected, and the infection status of PICC catheterization was observed. The risk factors of PICC catheterization infection were analyzed by multivariate Logistic regression analysis. The quality of life of all patients was evaluated by quality of life scale (QLQ-C30). Results: 17 cases of 198 patients had PICC catheterization infection, and the infection rate was 8.59%. All patients were divided into infection group (n=17) and non infection group (n=181) according to their infection status. Univariate analysis showed that PICC catheterization infection were not related to age, puncture times and puncture site(P>0.05), but were related to combination of underlying diseases, breast cancer taging, indentation season, catheterization time, chemotherapy times, dressing change days and white blood cell count(P<0.05). Logistic regression analysis showed that the white blood cell count>4× 10 9 /L, catheterization time≥ 10 months, indentation season in summer, chemotherapy times≥ 4 times, combined with underlying diseases, dressing change days >7 d were independent risk factors affecting local infection of PICC catheterization (P<0.05). The functional area, overall health status and total score of the non infection group were higher than those of the infection group, and the score of symptom area was lower than that of the infection group (P<0.05). Conclusion: Breast cancer patients with chemotherapy have a certain infection rate of PICC catheterization, and the quality of life of infected patients is significantly decreased. There are many factors that cause infection, which are related to the chemotherapy times, catheterization time, white blood cell count, combined with underlying diseases, the number of dressing change days, and the indwelling season. Clinical attention should be paid to minimize the occurrence of PICC local infection. [ABSTRACT FROM AUTHOR]

目的：分析乳腺癌化疗患者外周静脉置入中心静脉导管（PICC）置管感染的危险因素，并观察其生活质量。方法：选择 2019 年 1 月 ~2020 年 10 月期间来我院接受诊治的 198 例乳腺癌患者，搜集所有患者的一般资料，观察其 PICC 置管感染情况，采用多 因素 Logistic 回归分析 PICC 置管感染的危险因素。采用生活质量量表(QLQ-C30)评价所有患者的生活质量。结果：198 例患者中 有 17 例发生 PICC 置管感染，感染率为 8.59%。根据感染情况将所有患者分为感染组（n=17）和未感染组（n=181）。单因素分析结 果显示，PICC 置管感染与年龄、穿刺次数、穿刺部位无关（P>0.05），而与合并基础疾病、乳腺癌分期、留置季节、置管时间、化疗次 数、换药天数、白细胞计数有关（P<0.05）。经 Logistic 回归分析显示：白细胞计数 >4× 10 9 /L、置管时间 >10 个月、留置季节为夏季、 化疗次数≥ 4 次、合并基础疾病、换药天数 >7 d 是影响 PICC 置管局部感染的独立危险因素（P<0.05）。未感染组的功能领域、总体 健康状况、总分高于感染组，症状领域评分低于感染组（P<0.05）。结论：乳腺癌化疗患者具有一定的 PICC 置管感染率，且感染的 患者其生活质量明显下降，引起感染的因素较多，与化疗次数、置管时间、白细胞计数、合并基础疾病、换药天数、留置季节有关， 临床上需予以充分重视，以尽可能减少 PICC 局部感染现象的发生。 [ABSTRACT FROM AUTHOR]

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