miRNA: A Promising Therapeutic Target in Cancer.
In: International Journal of Molecular Sciences, Jg. 23 (2022-10-01), Heft 19, S. 11502-11530
Online
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Zugriff:
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy. [ABSTRACT FROM AUTHOR]
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miRNA: A Promising Therapeutic Target in Cancer.
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Autor/in / Beteiligte Person: | Menon, Amrutha ; Abd-Aziz, Noraini ; Khalid, Kanwal ; Poh, Chit Laa ; Naidu, Rakesh |
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Zeitschrift: | International Journal of Molecular Sciences, Jg. 23 (2022-10-01), Heft 19, S. 11502-11530 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1661-6596 (print) |
DOI: | 10.3390/ijms231911502 |
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