Non-criteria manifestations in the presence of antiphospholipid antibodies in a paediatric cohort.
In: Rheumatology, Jg. 61 (2022-11-01), Heft 11, S. 4465-4471
Online
academicJournal
Zugriff:
Objective To identify the variables associated with the development of non-criteria manifestations in the presence of antiphospholipid antibodies (aPLs) in a paediatric cohort. Methods Multicentric historical cohort study of children under the age of 18 years to determine thrombotic events (TEs) and non-criteria manifestations in the presence of aPL. Results Eighty-two children were included; 8.5% had at least one TE and 69.5% at least one non-criteria manifestation. Of them, 96.5% did not associate TEs. Haematological manifestations were the most frequent (43.65%), followed by cutaneous (22%), neurological (15.9%) and cardiac (4.9%) events. The most frequent aPLs were: 77.8% LA; 42.7% aCL and 41.5% aβ2GP. The positivity rate was: 64.6% simple, 18.3% double and 17.1% triple. ANA positivity was 68.1%. A bivariate analysis revealed that children with IgM aCL+, IgM aβ2GP+, ANA+, an SLE diagnosis or the absence of TEs had a significantly higher percentage of non-criteria manifestations (P <0.05). The logistic regression showed family history of autoimmune diseases [odds ratio (OR) 4.26, 95% CI: 0.8, 22.2, P =0.086] and the absence of TEs (OR 17.18, 95% CI: 1.2, 244.6, P =0.03) as independent risk factors of developing non-criteria manifestations. An SLE diagnosis, aPL profile and ANA+ were not identified. Conclusion Non-criteria manifestations were more frequent than TEs. A positive family history of autoimmune diseases and the absence of TEs were associated with a higher risk of developing non-criteria manifestations. Therefore, their inclusion as APS classification criteria should be considered in order to get an improved prognosis in the paediatric population. [ABSTRACT FROM AUTHOR]
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Non-criteria manifestations in the presence of antiphospholipid antibodies in a paediatric cohort.
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Autor/in / Beteiligte Person: | Morán-Álvarez, Patricia ; Andreu-Suárez, África ; Caballero-Mota, Liz ; Gassiot-Riu, Susanna ; Berrueco-Moreno, Rubén ; Calzada-Hernández, Joan ; Antón-López, Jordi ; Vázquez-Díaz, Mónica ; Boteanu, Alina |
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Zeitschrift: | Rheumatology, Jg. 61 (2022-11-01), Heft 11, S. 4465-4471 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1462-0324 (print) |
DOI: | 10.1093/rheumatology/keac070 |
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