Monocyte chemoattractant protein-1 levels are associated with major depressive disorder.
In: Journal of Basic & Clinical Physiology & Pharmacology, Jg. 33 (2022-11-01), Heft 6, S. 735-741
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Zugriff:
Major depressive disorder (MDD) is a distressing condition characterized by persistent low mood, loss of interest in daily activities. Researchers consider several biological, psycho-social, and genetic factors are involved in depression. The present study aimed to investigate the serum levels of monocyte chemoattractant protein-1 (MCP-1) in MDD patients to explore its role in depression. This case-control study recruited 114 MDD patients and 106 healthy controls (HCs) matched by age and gender. A specialized psychiatrist diagnosed the cases and evaluated the controls based on the diagnostic and statistical manual for mental disorders, 5th edition. We quantified serum MCP-1 levels using commercially available enzyme-linked immune sorbent assay kits. Also, we applied the Hamilton depression rating scale (Ham-D) to measure the severity of depression. We observed the decreased levels of serum MCP-1 in MDD patients compared to HCs. Also, we obtained a significant negative correlation between serum MCP-1 levels and Ham-D scores. Moreover, female MDD patients with higher Ham-D scores exhibited lower serum MCP-1 levels. The receiver operating characteristic analysis demonstrated the good diagnostic value of MCP-1 with the area under the curve at 0.837. The depression-related alteration of serum MCP-1 may be more complicated than the current assumption and depends on the characteristics of the individual patients. Our study suggests that the serum MCP-1 levels might involve in the pathophysiology and mechanism of MDD. The present findings, along with the diagnostic evaluation, might be used to evaluate depressive patients. [ABSTRACT FROM AUTHOR]
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Titel: |
Monocyte chemoattractant protein-1 levels are associated with major depressive disorder.
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Autor/in / Beteiligte Person: | Proma, Maliha Afrin ; Daria, Sohel ; Nahar, Zabun ; Ashraful Islam, Sardar Mohammad ; Bhuiyan, Mohiuddin Ahmed ; Islam, Md. Rabiul |
Zeitschrift: | Journal of Basic & Clinical Physiology & Pharmacology, Jg. 33 (2022-11-01), Heft 6, S. 735-741 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0792-6855 (print) |
DOI: | 10.1515/jbcpp-2021-0132 |
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