Temporal Variation in Disease Onset and Clinical Features of Lewy Body Disease in China.
In: Journal of Alzheimer's Disease, Jg. 90 (2022-12-01), Heft 3, S. 1263-1275
academicJournal
Zugriff:
Background: Lewy body dementia is the second most common neurodegenerative dementia, but data concerning the onset age and clinical features in the prodromal stage remain limited in China. Objective: To investigate the associations between onset age and clinical manifestations of cognitive impairment with Lewy bodies in a large-sample cohort. Methods: We included 74 patients with mild cognitive impairment with Lewy bodies (MCI-LB), 533 patients with dementia with Lewy bodies (DLB), 118 patients with Parkinson's disease with MCI (PD-MCI), and 313 patients with Parkinson's disease dementia (PDD) in this multicenter cohort from 22 memory clinics of China from 1 January 2018 to 31 March 2022. The onset age, clinical manifestations, and neuropsychological assessments were recorded and analyzed after reviewing the medical records. Results: The average onset age of memory loss was 68.28 (±7.00) years, and parkinsonism happened 2.00 (±1.24) years later for patients with MCI-LB. The average onset age of parkinsonism was 60.56 (±8.96) years, and the memory loss happened 3.49 (±3.02) years later for patients with PD-MCI. Rapid eye movement sleep behavior disorder and visual hallucinations were frequently reported in MCI-LB, DLB, and PDD, while visual hallucinations were least frequently reported in PD-MCI. Lower scores of MMSE and depression, and higher scores of activities of daily living and delusions, were independently associated with older onset age in DLB. Conclusion: The onset of PD-MCI precedes MCI-LB, and memory loss occurs 3 years after parkinsonism. The onset age is associated with cognition and neuropsychiatric symptoms in process. [ABSTRACT FROM AUTHOR]
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Titel: |
Temporal Variation in Disease Onset and Clinical Features of Lewy Body Disease in China.
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Autor/in / Beteiligte Person: | Gan, Jinghuan ; Chen, Zhichao ; Shi, Zhihong ; Li, Xudong ; Liu, Shuai ; Liu, Yiming ; Zhu, Hongcan ; Shen, Lu ; Zhang, Guili ; You, Yong ; Guo, Qihao ; Zhang, Nan ; Lv, Yang ; Gang, Baozhi ; Yuan, Junliang ; Ji, Yong |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 90 (2022-12-01), Heft 3, S. 1263-1275 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-220657 |
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