Double-Blind, Sham-Controlled Randomized Trial Testing the Efficacy of fMRI Neurofeedback on Clinical and Cognitive Measures in Children With ADHD.
In: American Journal of Psychiatry, Jg. 179 (2022-12-01), Heft 12, S. 947-958
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Zugriff:
Objective: Functional MRI neurofeedback (fMRI-NF) could potentially be a novel, safe nonpharmacological treatment for attention deficit hyperactivity disorder (ADHD). A proof-of-concept randomized controlled trial of fMRI-NF of the right inferior frontal cortex (rIFC), compared to an active control condition, showed promising improvement of ADHD symptoms (albeit in both groups) and in brain function. However, comparison with a placebo condition in a larger trial is required to test efficacy. Methods: This double-blind, sham-controlled randomized controlled trial tested the effectiveness and efficacy of fMRI-NF of the rIFC on symptoms and executive functions in 88 boys with ADHD (44 each in the active and sham arms). To investigate treatment-related changes, groups were compared at the posttreatment and 6-month follow-up assessments, controlling for baseline scores, age, and medication status. The primary outcome measure was posttreatment score on the ADHD Rating Scale (ADHD-RS). Results: No significant group differences were found on the ADHD-RS. Both groups showed similar decreases in other clinical and cognitive measures, except for a significantly greater decrease in irritability and improvement in motor inhibition in sham relative to active fMRI-NF at the posttreatment assessment, covarying for baseline. There were no significant side effects or adverse events. The active relative to the sham fMRI-NF group showed enhanced activation in rIFC and other frontal and temporo-occipital-cerebellar self-regulation areas. However, there was no progressive rIFC upregulation, correlation with ADHD-RS scores, or transfer of learning. Conclusions: Contrary to the hypothesis, the study findings do not suggest that fMRI-NF of the rIFC is effective in improving clinical symptoms or cognition in boys with ADHD. [ABSTRACT FROM AUTHOR]
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Titel: |
Double-Blind, Sham-Controlled Randomized Trial Testing the Efficacy of fMRI Neurofeedback on Clinical and Cognitive Measures in Children With ADHD.
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Autor/in / Beteiligte Person: | Lam, Sheut-Ling ; Criaud, Marion ; Lukito, Steve ; Westwood, Samuel J. ; Agbedjro, Deborah ; Kowalczyk, Olivia S. ; Curran, Sarah ; Barret, Nadia ; Abbott, Chris ; Liang, Holan ; Simonoff, Emily ; Barker, Gareth J. ; Giampietro, Vincent ; Rubia, Katya |
Zeitschrift: | American Journal of Psychiatry, Jg. 179 (2022-12-01), Heft 12, S. 947-958 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 0002-953X (print) |
DOI: | 10.1176/appi.ajp.21100999 |
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