Segmentectomy for clinically early-stage primary squamous cell carcinoma of the lung.
In: Thoracic Cancer, Jg. 13 (2022-12-15), Heft 24, S. 3477-3485
Online
academicJournal
Zugriff:
Background: Squamous cell carcinoma of the lung--the second most common subtype of lung cancer--has a poorer prognosis than lung adenocarcinoma. However, in contrast to lobectomy, the oncological outcomes after segmentectomy for primary squamous cell carcinomas remain unknown; hence, this study investigated these outcomes. Methods: Patients who underwent lobectomy or segmentectomy for clinically node-negative primary lung squamous cell carcinoma with a whole tumor size of ≤ 30 mm on preoperative computed tomography scan during April 2010 to December 2020 were included in this study. The cumulative incidence of recurrence (CIR) among all included patients and propensity score-matched patients were compared using the Gray method. Multivariate analysis using propensity scores and surgical procedures was performed using the Fine and Gray method. Results: Overall, 230 patients were included in this study; of these, 172 (74.8%) underwent lobectomy and 58 (25.2%) underwent segmentectomy. No significant differences were observed in the CIR between patients who underwent lobectomy and those who underwent segmentectomy (5-year rate 18.1% vs. 14.2%; p = 0.787). Moreover, no significant differences in CIR were observed between the propensity score-matched patients who underwent lobectomy (n = 43) and those who underwent segmentectomy (n = 43) (8.6% vs. 8.0%; p = 0.571). Multivariable analysis was performed for CIR using the propensity score; it revealed that segmentectomy was not a significant predictor of worse CIR (hazard ratio, 0.987; = 0.980). Conclusions: Segmentectomy may be feasible for treating clinically early-stage lung squamous cell carcinoma; its oncological outcomes are similar to those of lobectomy. [ABSTRACT FROM AUTHOR]
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Titel: |
Segmentectomy for clinically early-stage primary squamous cell carcinoma of the lung.
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Autor/in / Beteiligte Person: | Kagimoto, Atsushi ; Tsutani, Yasuhiro ; Shimada, Yoshihisa ; Mimae, Takahiro ; Miyata, Yoshihiro ; Ito, Hiroyuki ; Nakayama, Haruhiko ; Ikeda, Norihiko ; Okada, Morihito |
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Zeitschrift: | Thoracic Cancer, Jg. 13 (2022-12-15), Heft 24, S. 3477-3485 |
Veröffentlichung: | 2022 |
Medientyp: | academicJournal |
ISSN: | 1759-7706 (print) |
DOI: | 10.1111/1759-7714.14707 |
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