Autologous stem cell transplantation improves cardiopulmonary exercise testing outcomes in systemic sclerosis patients.
In: Rheumatology, Jg. 62 (2023-02-02), S. SI101- (6S.)
Online
academicJournal
Zugriff:
Objectives Autologous haematopoietic stem cell transplantation (AHSCT) is a disease-modifying treatment for patients with severe SSc. Here, we aimed at assessing cardiopulmonary function outcomes of SSc patients after AHSCT. Methods Twenty-seven SSc adult patients treated with AHSCT were included in this retrospective study. Most had the diffuse cutaneous subset (93%) and pulmonary involvement (85%). Before and 12 months after AHSCT, patients underwent cardiopulmonary exercise testing, transthoracic echocardiography, pulmonary function test with diffusing capacity for carbon monoxide (DLCO), 6-min walk test (6MWT) and quality of life evaluations. Results After AHSCT, the peak VO 2 increased from 954 to 1029 ml/min (P = 0.02), the percentage of predicted peak VO 2 increased from 48.9 to 53.5 m (P = 0.01), and the distance measured by the 6MWT increased from 445 to 502 m (P = 0.01), compared with baseline. Improvements in peak VO 2 correlated positively with improvements in 6MWT distance, and negatively with a decrease in resting heart rate. At baseline, patients with DLCO >70% had higher peak VO 2 values than those with DLCO <70% (P = 0.04), but after AHSCT all patients showed improved VO 2 values, regardless of baseline DLCO levels. Increases in VO 2 levels after AHSCT positively correlated with increases in the physical component scores of the Short Form-36 quality of life questionnaire (r = 0.70; P = 0.0003). Conclusion AHSCT improves the aerobic capacity of SSc patients probably reflecting combined increments in lungs, skeletal muscle and cardiac function. [ABSTRACT FROM AUTHOR]
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Titel: |
Autologous stem cell transplantation improves cardiopulmonary exercise testing outcomes in systemic sclerosis patients.
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Autor/in / Beteiligte Person: | Gadioli, Leonardo Pippa ; Costa-Pereira, Karla ; Dias, Juliana B E ; Moraes, Daniela A ; Crescêncio, Júlio C ; Schwartzmann, Pedro V ; Gallo-Júnior, Lourenço ; Schmidt, André ; Oliveira, Maria Carolina |
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Zeitschrift: | Rheumatology, Jg. 62 (2023-02-02), S. SI101- (6S.) |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1462-0324 (print) |
DOI: | 10.1093/rheumatology/keac413 |
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