Correlations between [ 68 Ga]Ga-DOTA-TOC Uptake and Absorbed Dose from [ 177 Lu]Lu-DOTA-TATE.
In: Cancers, Jg. 15 (2023-02-15), Heft 4, S. 1134-1146
Online
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Simple Summary: Peptide receptor radionuclide therapy (PRRT) with [ 177 Lu]Lu-DOTA-TATE is used to treat gastroenteropancreatic neuroendocrine tumours (GEP-NET) by targeting somatostatin receptors (SSTRs) found on the cell surface. High SSTR expression on [ 68 Ga]Ga-DOTA-TOC PET/CT decides patient eligibility. This study aimed to investigate potential correlations between therapeutic absorbed dose to tumours and pre-therapeutic [ 68 Ga]Ga-DOTA-TOC uptake, and found that the [ 68 Ga]Ga-DOTA-TOC PET imaging may predict the [ 177 Lu]Lu-DOTA-TATE uptake to a certain extent. However, there could be a high variance between predicted and actual absorbed doses for individual patients. Purpose: The aim of this paper was to investigate correlations between pre- therapeutic [ 68 Ga]Ga-DOTA-TOC uptake and absorbed dose to tumours from therapy with [ 177 Lu]Lu-DOTA-TATE. Methods: This retrospective study included 301 tumours from 54 GEP-NET patients. The tumours were segmented on pre-therapeutic [ 68 Ga]Ga-DOTA-TOC PET/CT, and post-therapy [ 177 Lu]Lu-DOTA-TATE SPECT/CT images, using a fixed 40% threshold. The SPECT/CT images were used for absorbed dose calculations by assuming a linear build-up from time zero to day one, and mono-exponential wash-out after that. Both SUV mean and SUV max were measured from the PET images. A linear absorbed-dose prediction model was formed with SUV mean as the independent variable, and the accuracy was tested with a split 70–30 training-test set. Results: Mean SUV mean and SUV max from [ 68 Ga]Ga-DOTA-TOC PET was 24.0 (3.6–84.4) and 41.0 (6.7–146.5), and the mean absorbed dose from [ 177 Lu]Lu-DOTA-TATE was 26.9 Gy (2.4–101.9). A linear relationship between SUV mean and [ 177 Lu]Lu-DOTA-TATE activity concentration at 24 h post injection was found (R 2 = 0.44, p < 0.05). In the prediction model, a root mean squared error and a mean absolute error of 1.77 and 1.33 Gy/GBq, respectively, were found for the test set. Conclusions: There was a high inter- and intra-patient variability in tumour measurements, both for [ 68 Ga]Ga-DOTA-TOC SUVs and absorbed doses from [ 177 Lu]Lu-DOTA-TATE. Depending on the required accuracy, [ 68 Ga]Ga-DOTA-TOC PET imaging may estimate the [ 177 Lu]Lu-DOTA-TATE uptake. However, there could be a high variance between predicted and actual absorbed doses. [ABSTRACT FROM AUTHOR]
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Titel: |
Correlations between [ 68 Ga]Ga-DOTA-TOC Uptake and Absorbed Dose from [ 177 Lu]Lu-DOTA-TATE.
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Autor/in / Beteiligte Person: | Bruvoll, Ragnar ; Blakkisrud, Johan ; Mikalsen, Lars Tore ; Connelly, James ; Stokke, Caroline |
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Zeitschrift: | Cancers, Jg. 15 (2023-02-15), Heft 4, S. 1134-1146 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 2072-6694 (print) |
DOI: | 10.3390/cancers15041134 |
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