A Phase 1b Clinical Study of Intravenous AAVrh10 Vector Expressing GALC in Krabbe Subjects Who Previously Received Hematopoietic Stem Cell Transplantation (REKLAIM).

Keywords: Adeno-Associated Virus; Bioengineering; Biologics; Biomedicine; Biotechnology; Biotechnology - Gene Therapy; Bone Marrow Cells; Cell Transplantation; Cell Transplants; Clinical Research; Clinical Trials and Studies; Diagnostics and Screening; Drugs and Therapies; Gene Therapy; Genetic Engineering; Genetically-Engineered Proteins; Genetics; Globoid Cell Leukodystrophy; Health and Medicine; Hematology; Hematopoietic; Hematopoietic Stem Cells; Krabbe Disease; Nutritional and Metabolic Diseases and Conditions; Post-Trial Research; Stem Cell Research; Surgery; Therapy; Transplant Medicine; Virology EN Adeno-Associated Virus Bioengineering Biologics Biomedicine Biotechnology Biotechnology - Gene Therapy Bone Marrow Cells Cell Transplantation Cell Transplants Clinical Research Clinical Trials and Studies Diagnostics and Screening Drugs and Therapies Gene Therapy Genetic Engineering Genetically-Engineered Proteins Genetics Globoid Cell Leukodystrophy Health and Medicine Hematology Hematopoietic Hematopoietic Stem Cells Krabbe Disease Nutritional and Metabolic Diseases and Conditions Post-Trial Research Stem Cell Research Surgery Therapy Transplant Medicine Virology 2023 MAR 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- Staff editors report on the newly launched clinical trial, NCT05739643, which has the following summary description: "This is a non-blinded, non-randomized dose escalation study of intravenous FBX-101 in which subjects who have previously received hematopoietic stem cell transplant will receive a single infusion of an adeno-associated virus gene therapy product. Conditions for combining gene therapy with bone marrow transplantation in murine Krabbe disease. [Extracted from the article]

Copyright of Stem Cell Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)