بررسي ميزان اپيورفين بزاق در مبتلايان به درد آتيپيك صورتي. (Arabic)

Background and Aims: Atypical facial pain (AFP) is a chronic disease associated with local pain in the craniofacial area. A wide range of treatments including drug therapy, psychiatric methods and open surgery are used for its treatment. Opiorphin is a pentapeptide that can block pain and also has proven antidepressant effects. The aim of this study was conducted to investigate the opiorphin concentration in AFP patients and to compare it with healthy people. Materials and Methods: This study was performed on 30 AFP patients and 40 healthy individuals. Unstimulated saliva was collected from both groups by spitting method. HAD-A (Hamilton Anxiety Test) and HAD-D (Hamilton Depression Test) questionnaires were completed for all patients and controls. Psychological interview with the patients and psychological analysis were performed to determine anxiety and depression scores. Data analysis was done using SPSS (ver.24) statistical software Results: The subjects of two groups were homogeneous in terms of age and sex. The mean salivary opiorphin concentrations in the case and control groups were 1.8050±0.2923 and 1.8032±0.3682 ng/ml, respectively. According to the results of t-Test, no significant difference was observed in the mean opiorphin concentration between the AFP group and control group (P=1.000). According to the Pearson's test, no significant relationship was found between the opiorphin levels and the age, sex, and anxiety or depression score in the patient and control groups (P>0.05). Also, there was no remarkable correlation between initial VAS, duration of pain and previous treatments with opiorphin levels in the AFP patients (P>0.05). No significant correlation was found between the opiorphin concentration and menopausal period in the case and control women (P>0.05). Conclusion: The results showed that most AFP patients had some degree of anxiety and depression. However, salivary opiorphin concentration did not significantly increase in the AFP patients. [ABSTRACT FROM AUTHOR]

زمينه و هدف: درد آتيپيك صورت (pain facial atypical) (AFP (بيماري مزمني است كه با درد موضعي در ناحيه جمجمهاي- صــورتي همراه اســت. طيف گســتردهاي از درمان ها شــامل درمان دارويي، روشهاي روانشناختي و عمل جراحي باز براي درمان آن استفاده ميشود. اپيورفين يك پنتا پپتيد است كه ميتواند مانع از درد شــود و همچنين اثرات ضــد افســردگي ثابت شــده دارد. اين مطالعه با هدف بررســي غلظت اپيورفين در بيمارانAFP و مقايسه آن با افراد سالم انجام شد. روش بررســي: اين مطالعه بر روي ٣٠ بيمار AFP و ٤٠ نفر فرد ســـالم انجام شـــد. از هر دو گروه بزاق غير تحريكي به روش spitting) تف كردن) تهيه شـــد. براي كليه بيماران و افراد گروه شـــاهد پرســـشـــنامه مصاحبه و شده تكميل) Hamilton Depression Test) HAD-D و) Hamilton Anxiety Test) HAD-A و آناليز روان شناختي بيماران جهت تعيين درجه ا ضطراب و اف سردگي آنان انجام شد. تجزيه و تحليل دادهها با استفاده از نرم افزار آماري SPSS) نسخه ٢٤ (انجام شد. يافتهها: بيماران دو گروه از نظر متغير ســـن و جنس همگن بودند. ميانگين غلظت اپيورفين بزاق در كل بيماران گروه مورد و گروه شاهد، به ترتيب ٢٩٢٣/٠±٨٠٥٠/١ و ٣٦٨٢/٠±٨٠٣٢/١نانو گرم در ميلي ليتر بود. با توجه به نتيجه test-T در ميانگين غلظت اپيورفين بين گروه AFP و شاهد اختلاف معنيداري مشاهده نشد (٠٠٠/١=P .(آزمون پيرسون نشان داد كه ارتباط معنيداري بين سن، جنس، نمره اضطراب و افسردگي در گروه بيماران و افراد شـاهد وجود ندارد (٠٥/٠>P .(همچنين ارتباط معنيداري بين VAS اوليه، مدت ابتلا به بيماري و انجام درمان قبلي در گروه بيماران با غلظت اپيورفين وجود ندارد (٠٥/٠>P .(ارتباط معنيداري بين شـــروع دوره يائسگي زنان در گروه بيماران و افراد شاهد با غلظت اپيورفين اوليه نيز يافت نشد (٠٥/٠>P .( نتيجه گيري: نتايج نشـان داد اكثر بيماران AFP درجاتي از اضـطراب و افسـردگي داشـتند، هر چند غلظت اپيورفين بزاقي در مبتلايان به AFP افزايش معنيداري نداشت. [ABSTRACT FROM AUTHOR]

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