Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.
In: Oncogene, Jg. 24 (2005-03-03), Heft 10, S. 1711-1717
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Zugriff:
Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 receptor and has been implicated in regulating proliferation, survival, or both properties of EBV-infected cells. We established a conditional LMP1 allele in the context of the intact EBV genome to define the immediate-early cellular target genes regulated by LMP1 in order to assess its contributions to infected human B cells. The functional analysis of this conditional system indicated that LMP1 specifically induces mitogenic B-cell activation through c-myc and Jun/AP1 family members and confirms its direct role in upregulating expression of multiple genes with opposing activities involved in cell survival. LMP1's signals were found to be essential for the G 1 /S transition in human B cells; cells lacking LMP1's signals are cell cycle arrested and survive quiescently. LMP1's activities are therefore not required to maintain survival in nonproliferating cells. LMP1 does induce both pro- and antiapoptotic genes whose balance seems to permit survival during LMP1's induction and maintenance of proliferation.Oncogene (2005) 24, 1711-1717. doi:10.1038/sj.onc.1208367 Published online 17 January 2005 [ABSTRACT FROM AUTHOR]
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Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.
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Autor/in / Beteiligte Person: | Dirmeier, Ulrike ; Hoffmann, Reinhard ; Kilger, Ellen ; Schultheiss, Ute ; Briseño, Cinthia ; Gires, Olivier ; Kieser, Arnd ; Eick, Dirk ; Sugden, Bill ; Hammerschmidt, Wolfgang |
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Zeitschrift: | Oncogene, Jg. 24 (2005-03-03), Heft 10, S. 1711-1717 |
Veröffentlichung: | 2005 |
Medientyp: | academicJournal |
ISSN: | 0950-9232 (print) |
DOI: | 10.1038/sj.onc.1208367 |
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