A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry.
In: Journal of Women's Health (15409996), Jg. 32 (2023-04-01), Heft 4, S. 423-433
academicJournal
Zugriff:
Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not seeking fertility and undergo a hysterectomy, abdominal myomectomy (AM), or uterine artery embolization (UAE). Materials and Methods: The Comparing Options for Management: Patient-Centered Results for Uterine Fibroids (COMPARE-UF) Registry is a multi-institutional prospective observational cohort study of patients treated for SUF. A subset of 1465 women 31–45 years of age, who underwent either hysterectomy (n = 741), AM (n = 446), or UAE (n = 155) were included in this analysis. Demographics, fibroid history, and symptoms were obtained by baseline questionnaires and at 1 year post-treatment. Results were stratified by all treatments and propensity score weighting to adjust for differences in baseline characteristics. Results: Women undergoing UAE reported the lowest baseline HR-QoL and highest SS scores (mean = 40.6 [standard deviation (SD) = 23.8]; 62.3 [SD = 24.2]) followed by hysterectomy (44.3 [24.3]; 59.8 [SD = 24.1]). At 12 months, women who underwent a hysterectomy experienced the largest change in both HR-QoL (48.7 [26.2]) and SS (51.9 [25.6]) followed by other uterine-sparing treatments. Propensity score weighting revealed all treatments produced substantial improvement, with hysterectomy patients reporting the highest HR-QoL score (92.0 [17.8]) compared with myomectomy (86.7 [17.2]) and UAE (82.6 [21.5]) (p < 0.0001). Similarly, hysterectomy patients reported the lowest SS scores (8.2 [15.1]) compared with myomectomy (16.5 [15.1]) and UAE (19.6 [17.5]) (p < 0.0001). Conclusion: All procedures showed improvement in HR-QoL and reduction in SS score at 12 months, hysterectomy showing maximum improvement. Of importance, at 12 months, patients who underwent either a myomectomy or UAE reported comparable symptom relief and HR-QoL. Clinicaltrials.Gov Identifier: NCT02260752. [ABSTRACT FROM AUTHOR]
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A Comparative Analysis of Health-Related Quality of Life 1 Year Following Myomectomy or Uterine Artery Embolization: Findings from the COMPARE-UF Registry.
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Autor/in / Beteiligte Person: | Anchan, Raymond M. ; Wojdyla, Daniel ; Bortoletto, Pietro ; Terry, Kathryn ; Disler, Emily ; Milne, Ankrish ; Gargiulo, Antonio ; Petrozza, John ; Brook, Olga ; Srouji, Serene ; Morton, Cynthia C. ; Greenberg, James ; Wegienka, Ganesa ; Stewart, Elizabeth A. ; Nicholson, Wanda K. ; Thomas, Laine ; Venable, Sateria ; Laughlin-Tommaso, Shannon ; Diamond, Michael P. ; Maxwell, G. Larry |
Zeitschrift: | Journal of Women's Health (15409996), Jg. 32 (2023-04-01), Heft 4, S. 423-433 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1540-9996 (print) |
DOI: | 10.1089/jwh.2022.0133 |
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