"Novel Design Of Guide Rna And Uses Thereof" in Patent Application Approval Process (USPTO 20230086489).
In: Gene Therapy Weekly, 2023-04-13, S. 3367-3367
serialPeriodical
Zugriff:
"In some embodiments, the Cas13 effector protein is a Cas13a effector protein, a Cas13b effector protein, a Cas13c effector protein, a Cas13d effector protein, a Cas13e effector protein, or a Cas13f effector protein. "In some embodiments, the parental or wild-type Cas13 effector protein is a Cas13a effector protein, a Cas13b effector protein, a Cas13c effector protein, a Cas13d effector protein, a Cas13e effector protein, or a Cas13f effector protein. "Another aspect of the disclosure provides a modified Cas13 protein with both HEPN1 and HEPN2 domains substantially removed from a parental or wild-type Cas13 effector protein (e.g., substantially lacking both the HEPN1 and HEPN2 domains of the parental or wild-type Cas13 effector protein), with the proviso that the modified Cas13 protein is not minidCas13e.1-N180+C150. "In some embodiments, the Cas effector protein is a Class 2, Type VI-E (Cas13e) Cas effector protein (e.g., SEQ ID NO: 1), and wherein the crRNA binding domain lacks about 180 (e.g., 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, or 190) N-terminal residues, and lacks about 150 (e.g., 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, or 160) C-terminal residues of the Cas13e effector protein (e.g., SEQ ID NO: 1). [Extracted from the article]
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Titel: |
"Novel Design Of Guide Rna And Uses Thereof" in Patent Application Approval Process (USPTO 20230086489).
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Zeitschrift: | Gene Therapy Weekly, 2023-04-13, S. 3367-3367 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1078-2842 (print) |
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