Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children.
In: Journal of the Pediatric Infectious Diseases Society, Jg. 12 (2023-03-01), Heft 3, S. 173-176
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Zugriff:
We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was appropriately restricted in replication in adults and HPIV2-seropositive children but was overattenuated for HPIV2-seronegative children. [ABSTRACT FROM AUTHOR]
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| Titel: |
Evaluation of a Live-Attenuated Human Parainfluenza Virus Type 2 Vaccine in Adults and Children.
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| Autor/in / Beteiligte Person: | Karron, Ruth A ; Herbert, Kristi ; Wanionek, Kimberli ; Schmidt, Alexander C ; Schaap-Nutt, Anne ; Collins, Peter L ; Buchholz, Ursula J |
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| Zeitschrift: | Journal of the Pediatric Infectious Diseases Society, Jg. 12 (2023-03-01), Heft 3, S. 173-176 |
| Veröffentlichung: | 2023 |
| Medientyp: | academicJournal |
| ISSN: | 2048-7193 (print) |
| DOI: | 10.1093/jpids/piac137 |
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