DIAGNOSIS AND TREATMENT OF AUTOIMMUNE THROMBOCYTOPENIA.

A descriptive, retrospective study was carried out in which the clinical manifestations and treatment results were analyzed in 45 patients with the diagnosis of autoimmune idiopathic thrombocytopenia, who were on record in the Hematology Department and the Consultative Center of the Oncology Institute during the years 2017- 2022. The study showed that idiopathic autoimmune thrombocytopenia was determined more frequently in people aged 30-49 years (46.6%) and predominated in women (65%), and the hemorrhagic syndrome was more frequently manifested by petechiae (62.2%), ecchymosis (55.5%), less often - epistaxis (26.66%) and gingivoragia (24.4%). In most cases (71.2%), in the general blood analysis the platelets were solitary, less often the platelets constituted 20-50x109/l (28.8%) and in the bone marrow examination more frequently (51.6%) an increase in megakaryocytes with a decrease in platelets was determined, and in 22.5% of cases with a decrease in platelets, a decrease in megakaryocytes also occurred. It was also determined that treatment efficacy was higher when splenectomy was performed. The 5-year progression-free survival of patients with splenectomy was 91%, as opposed to progressionfree survival of 17% for patients treated with glucocorticoids. [ABSTRACT FROM AUTHOR]

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