Randomised trial on the influence of continuous magnesium infusion on arrhythmias following cardiopulmonary bypass surgery for congenital heart disease.
In: Intensive Care Medicine, Jg. 29 (2003-07-01), Heft 7, S. 1141-1144
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Objectives: To check the hypothesis that continuous magnesium infusion protects the heart from arrhythmias following cardiopulmonary bypass surgery for congenital heart disease. Design: A prospective randomised placebo-controlled study, with patients stratified in three weight groups. Patients and Participants: The study group ( n=65) postoperatively received a magnesium infusion (1 mmol/kg), the control group ( n=66) received placebo. In both groups serum and ionised magnesium values were followed, and all postoperative arrhythmias were documented for 24 h. Measurements and Results: Serum and ionised magnesium in the blood was elevated after the end of bypass (0.54+/-0.15 mmol l(-1) pre-operatively, 0.88+/-0.24 mmol l(-1) postoperatively), where a cardioplegia solution containing magnesium was used. Magnesium values remained at this elevated level in the magnesium therapy group, and decreased to normal pre-operative values within 24 h in controls ( P<0.001). The incidence of postoperative arrhythmias was lower in the study group: 8/65 in the study group and 17/66 in the control group, respectively (chi-squared test, P=0.05). Lower patient weight (32.7 kg versus 22.6 kg), longer cardiopulmonary bypass time (128.7 min versus 87.9 min) and deeper body temperature during extracorporeal circulation (29.2 degrees C versus 32.6 degrees C) were identified as risk factors for postoperative arrhythmias ( P<0.05). Conclusions: Continuous magnesium infusion effectively reduces the rate of arrhythmias following cardiopulmonary bypass surgery for congenital heart disease and should, therefore, be routinely used. [ABSTRACT FROM AUTHOR]
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Titel: |
Randomised trial on the influence of continuous magnesium infusion on arrhythmias following cardiopulmonary bypass surgery for congenital heart disease.
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Autor/in / Beteiligte Person: | Dittrich, S. ; Germanakis, J. ; Dähnert, I. ; Stiller, B. ; Dittrich, H. ; Vogel, M. ; Lange, P. E. ; Dähnert, I |
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Zeitschrift: | Intensive Care Medicine, Jg. 29 (2003-07-01), Heft 7, S. 1141-1144 |
Veröffentlichung: | 2003 |
Medientyp: | academicJournal |
ISSN: | 0342-4642 (print) |
DOI: | 10.1007/s00134-003-1802-3 |
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