慢性牙周炎患者血清 CGRP、PGE2、CCL20 与牙周临床指标 和 Th17/Treg 失衡的相关性分析. (Chinese)

Objective:To explore the correlation between serum calcitonin gene related peptide (CGRP),prostaglandin E2(PGE2),CC chemokine ligand 20 (CCL20) with periodontal clinical indicators and helper T lymphocyte 17/regulatory T lymphocyte (Th17/Treg)imbalance in patients with chronic periodontitis.Methods:91 patients with chronic periodontitis who were admitted to Hainan Women and Children Medical Center from May 2020 to May 2022 were selected,and they were divided into mild group (39 cases),moderate group(36 cases) and severe group (16 cases) according to their severity.Serum CGRP,PGE2,CCL20,periodontal clinical indicators[bleeding index(BI),probing depth(PD),attachment loss (AL),plaque index (PLI)],peripheral blood Th17 cell ratio,Treg cell ratio,and Th17/Treg ratio were compared in the three groups.Pearson correlation was used to analyze the correlation between serum CGRP,PGE2,CCL20and periodontal clinical indicators and Th17/Treg imbalance.Results:Compared with the mild group,the serum CGRP and Treg cells proportion in the moderate group and severe group were significantly decreased(P＜0.05),and the serum PGE2,CCL20,BI,PD,PLI,AL,Th17 cells proportion and Th17/Treg ratio were significantly increased (P＜0.05).Compared with the moderate group,the serum CGRP and Treg cells proportion in the severe group were significantly decreased (P＜0.05),while the serum PGE2,CCL20,BI,PD,PLI,AL,Th17 cells proportion and Th17/Treg ratio were significantly increased (P＜0.05).The correlation results showed that serum PGE2and CCL20 levels were positively correlated with the BI,PD,PLI,AL,Th17 cells proportion and Th17/Treg ratio (P＜0.05),and negatively correlated with the Treg cells proportion (P＜0.05).Serum CGRP level was negatively correlated with BI,PD,PLI,AL,the Th17 cells proportion and Th17/Treg ratio(P＜0.05),and positively correlated with the Treg cells proportion (P＜0.05).Conclusion:Serum CGRP,PGE2and CCL20 levels in patients with chronic periodontitis are significantly related to the severity of the disease,periodontal clinical indicators and Th17/Treg imbalance.Serum CGRP,PGE2and CCL20 may participate in the occurrence and development of chronic periodontitis by affecting the Th17/Treg balance. [ABSTRACT FROM AUTHOR]

探究慢性牙周炎患者血清降钙素基因相关肽（CGRP）, 前列腺素 E（2 PGE2）, CC 趋化因子配体 20（CCL20）与牙周临床 指标和辅助性 T 淋巴细胞 17/ 调节性 T 淋巴细胞（Th17/Treg）失衡的相关性。方法：选取 2020 年 5 月 -2022 年 5 月海南省妇女儿 童医学中心收治的 91 例慢性牙周炎患者，根据其严重程度分为轻度组（39 例）, 中度组（36 例）, 重度组（16 例），比较三组血清 CGRP, PGE2, CCL20, 牙周临床指标[出血指数（BI）, 探诊深度（PD）, 附着丧失（AL）, 菌斑指数（PLI）], 外周血 Th17 细胞比例, Treg 细胞比例, Th17/Treg 比值，采用 Pearson 相关分析血清 CGRP, PGE2, CCL20 与牙周临床指标和 Th17/Treg 失衡的相关性。结果： 与轻度组比较，中度组, 重度组血清 CGRP, Treg 细胞比例显著降低（P＜0.05），血清 PGE2, CCL20, BI, PD, PLI, AL, Th17 细胞比 例, Th17/Treg 比值显著增高（P＜0.05）；与中度组比较，重度组血清 CGRP, Treg 细胞比例显著降低（P＜0.05），血清 PGE2, CCL20, BI, PD, PLI, AL, Th17 细胞比例, Th17/Treg 比值显著增高（P＜0.05）。相关性结果提示，血清 PGE2, CCL20 水平与 BI, PD, PLI, AL, Th17 细胞比例, Th17/Treg 比值呈正相关（P＜0.05），与 Treg 细胞比例呈负相关（P＜0.05）；血清 CGRP 水平与 BI, PD, PLI, AL, Th17 细胞比例, Th17/Treg 比值呈负相关（P＜0.05），与 Treg 细胞比例呈正相关（P＜0.05）。结论：慢性牙周炎患者血清 CGRP, PGE2, CCL20 水平与疾病严重程度, 牙周临床指标及 Th17/Treg 失衡显著相关，血清 CGRP, PGE2, CCL20 可能通过影响 Th17/Treg 平衡参与慢性牙周炎的发生和发展。 [ABSTRACT FROM AUTHOR]

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