环状 RNA 在肝细胞癌发生发展及诊疗中的作用. (Chinese)
In: Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, Jg. 39 (2023-08-01), Heft 8, S. 1983-1991
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Zugriff:
As the most common type of primary liver cancer, hepatocellular carcinoma (HCC) is an invasive and fatal malignant tumor, and its development and progression involve multiple genes, steps, and stages. Circular RNA (circRNA), as a class of endogenous non-coding RNAs, mainly acts as a sponge by absorbing microRNA or RNA-binding proteins to regulate the expression of downstream target genes. This article comprehensively introduces the role and significance of circRNA in signal transduction, immunity, metabolism, drug resistance, and hepatitis B virus-related HCC and its potential value as a biomarker or therapeutic target for HCC, so as to provide new ideas for the diagnosis and treatment of HCC. [ABSTRACT FROM AUTHOR]
肝细胞癌 (HCC) 作为原发性肝癌最常见的类型, 是一种具有侵袭性且致命的恶性肿瘤, 其发生发展是一个多基因参与、多步骤、多阶段的过程. 环状RNA (circRNA) 作为一类内源性非编码RNA,主要通过吸附微小RNA (miRNA) 或者RNA结合蛋白 (RBP) 发挥“海绵作用”,进而调控下游靶基因表达. 本文全面介绍了circRNA在HCC信号转导、免疫、代谢、耐药、HBV相关HCC中的作用及意义, 及其作为HCC的生物标志物或治疗靶点的潜在价值, 为HCC的诊断和治疗提供新思路. [ABSTRACT FROM AUTHOR]
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Titel: |
环状 RNA 在肝细胞癌发生发展及诊疗中的作用. (Chinese)
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Autor/in / Beteiligte Person: | 苗淑莹 ; 杨军 ; 管文燕 ; 张标 ; 何璐 ; 樊智文 |
Zeitschrift: | Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, Jg. 39 (2023-08-01), Heft 8, S. 1983-1991 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1001-5256 (print) |
DOI: | 10.3969/j.issn.1001-5256.2023.08.033 |
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