Surgical Margin Affects the Long-Term Prognosis of Patients With Hepatocellular Carcinoma Undergoing Radical Hepatectomy Followed by Adjuvant TACE.
In: Oncologist, Jg. 28 (2023-08-01), Heft 8, S. e633- (12S.)
Online
academicJournal
Zugriff:
Background The aim of this study was to investigate whether postoperative adjuvant transcatheter arterial chemoembolization (TACE) treatment in wide- and narrow-margin groups could improve the long-term prognosis of patients with hepatocellular carcinoma (HCC). Materials and Methods A total of 670 patients with HCC who underwent radical hepatectomy from January 2016 to December 2017 were enrolled, including 397 patients and 273 patients in the wide- and narrow-margin groups. Recurrence-free survival (RFS) and overall survival (OS) outcomes were compared in the wide-margin and narrow-margin groups with and without adjuvant TACE postoperatively, respectively. Propensity score matching (PSM) analysis was used to match patients between TACE and no TACE groups in a 1:1 ratio. Results The wide-margin resection was associated with better RFS and OS rates than narrow-margin resection for patients with HCC. Patients with postoperative adjuvant TACE had a better RFS and OS than patients without postoperative adjuvant TACE in the narrow-margin group and reduced the intrahepatic recurrence rate (39.1% vs. 52.6%, P =.036) and the local recurrence rate in the liver (11.2% vs. 21.4%, P =.032). But postoperative adjuvant TACE did not alter recurrence and survival outcomes in the wide-margin group. Similar results were noted after propensity score matching (PSM). Conclusion The wide-margin resection had better RFS and OS than the narrow-margin resection for patients with HCC. Postoperative adjuvant TACE was associated with reduced recurrence and improved OS after narrow-margin resection, but was not effective in the wide-margin resection. [ABSTRACT FROM AUTHOR]
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Titel: |
Surgical Margin Affects the Long-Term Prognosis of Patients With Hepatocellular Carcinoma Undergoing Radical Hepatectomy Followed by Adjuvant TACE.
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Autor/in / Beteiligte Person: | Bai, Shilei ; Yang, Pinghua ; Liu, Jianwei ; Xue, Hui ; Xia, Yong ; Liu, Fuchen ; Yang, Zhao ; Zhang, Lei ; Wu, Yeye ; Shen, Feng ; Wang, Kui |
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Zeitschrift: | Oncologist, Jg. 28 (2023-08-01), Heft 8, S. e633- (12S.) |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1083-7159 (print) |
DOI: | 10.1093/oncolo/oyad088 |
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