Clinical impact of myosteatosis measured by magnetic resonance imaging on long-term outcomes of hepatocellular carcinoma after radical hepatectomy.
In: BMC Surgery, Jg. 23 (2023-09-15), Heft 1, S. 1-8
Online
academicJournal
Zugriff:
Aims: A variety of factors have been reported to affect long-term outcomes after radical resection of hepatocellular carcinoma (HCC). However, the indicators remain controversial. The purpose of this study was to evaluate the relationship between myosteatosis of the multifidus muscle and long-term outcomes after radical surgery for HCC. Methods: We retrospectively analyzed clinicopathological data for 187 patients with HCC who underwent radical surgery at Tokushima University between January 2009 and December 2020 and measured the density of fat in the multifidus muscle at L3 on their preoperative magnetic resonance images (MRI). Associations of myosteatosis and clinicopathological factors with long-term outcomes were evaluated. Results: The patients were divided into a myosteatosis-negative group (n = 122) and a myosteatosis-positive group (n = 65). The cancer-specific survival rate after hepatectomy was significantly worse in the myosteatosis-positive group than in the myosteatosis-negative group (p = 0.03). Univariate analysis identified multiple tumors, stage III/IV disease, an alfa-fetoprotein level ≥ 10 ng/ml, PIVKA-II ≥ 400 AU/ml, vp(+) status, and myosteatosis to be prognostic factors for cancer-specific survival. Multivariate analysis revealed multiple tumors, an alfa-fetoprotein level ≥ 10 ng/ml, and myosteatosis to be independent prognostic factors. Conclusions: Myosteatosis measured by MRI is a simple and useful predictor of the long-term outcome after radical surgery for HCC. [ABSTRACT FROM AUTHOR]
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Titel: |
Clinical impact of myosteatosis measured by magnetic resonance imaging on long-term outcomes of hepatocellular carcinoma after radical hepatectomy.
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Autor/in / Beteiligte Person: | Yoshikawa, Kozo ; Shimada, Mitsuo ; Morine, Yuji ; Ikemoto, Tetsuya ; Saito, Yu ; Yamada, Shinichiro ; Teraoku, Hiroki ; Takao, Shoichiro |
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Zeitschrift: | BMC Surgery, Jg. 23 (2023-09-15), Heft 1, S. 1-8 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1471-2482 (print) |
DOI: | 10.1186/s12893-023-02188-z |
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