Cooperative assistance of a sulfonamide in a proline-mediated direct asymmetric aldol addition.
In: New Journal of Chemistry, Jg. 47 (2023-09-28), Heft 36, S. 17042-17050
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Zugriff:
A sulfonamide moiety was introduced at the C-4 position of proline, cis to the –COOH group, to examine a possible intramolecular synergistic interaction between the two functional groups and the consequent influence on the enamine mediated asymmetric aldol reaction. The resultant catalyst was proficient in furnishing the aldol adducts in commendable yields, along with excellent diastereo- and enantioselectivities in the presence of water. The proposed cooperative assistance was also the subject of a brief computational study to gain a deeper insight. [ABSTRACT FROM AUTHOR]
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Titel: |
Cooperative assistance of a sulfonamide in a proline-mediated direct asymmetric aldol addition.
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Autor/in / Beteiligte Person: | Kumari, Kiran ; Bhati, Meeta ; Madhukar, Roopendra Singh ; Khan, Akram Gulam Hussain ; Janjani, Prachi ; Rajagopala Reddy, S. ; Easwar, Srinivasan |
Zeitschrift: | New Journal of Chemistry, Jg. 47 (2023-09-28), Heft 36, S. 17042-17050 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1144-0546 (print) |
DOI: | 10.1039/d3nj02685j |
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