Researchers Submit Patent Application, "Insulin Receptor-Mediated Enhancement Of Gene Transfer", for Approval (USPTO 20230295238).

Some modified capsid proteins of the invention contain an AAV cap protein VP1 sequence with an inserted IR-binding peptide. Some of these modified capsid proteins contain an amino acid sequence as shown in any one of SEQ ID NOs:1-5, or a conservatively modified variant "In some related aspects, the invention provides modified viral capsid that contain one or more of the modified capsid proteins described herein. The modified capsid protein contain a viral capsid polypeptide sequence that is conjugated to an insulin receptor (IR) binding moiety. [Extracted from the article]

Copyright of Gene Therapy Weekly is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)