"Composition And Method" in Patent Application Approval Process (USPTO 20230295237).
In: Gene Therapy Weekly, 2023-10-09, S. 3095-3095
serialPeriodical
Zugriff:
The AAV capsid protein of any one of claims 1 to 6, wherein: (a) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 11; (b) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 12; (c) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 13; (d) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 14; (e) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 15; (f) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 16; (g) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 17; (h) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 18; or (i) the AAV capsid protein has the amino acid sequence of SEQ ID NO: 19. The AAV capsid protein of any one of claims 1 to 4, wherein the unmodified AAV capsid protein is a wild-type PHP.eB capsid protein, or an AAV capsid protein comprising a sequence having at least 80% sequence identity to SEQ ID NO: 10. The AAV capsid protein of claim 1, wherein the amino acid sequence insertion results in increased transduction efficiency in microglia or brain macrophages compared to an AAV capsid protein without the amino acid insertion. [Extracted from the article]
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Titel: |
"Composition And Method" in Patent Application Approval Process (USPTO 20230295237).
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Zeitschrift: | Gene Therapy Weekly, 2023-10-09, S. 3095-3095 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1078-2842 (print) |
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