Poor reporting quality of randomized controlled trials comparing treatments of COVID-19–A retrospective cross-sectional study on the first year of publications.
In: PLoS ONE, Jg. 18 (2023-10-16), Heft 10, S. 1-15
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Zugriff:
Introduction: Transparent and complete reporting of randomized controlled trials (RCTs) is essential for critical scientific appraisal of the results. It has been argued whether publications during the COVID-19 pandemic have met reporting standards. In this study, we assessed reporting adherence of RCTs on treatment interventions in COVID-19 patients to the CONSORT checklist and discuss which lessons can be learned to improve reporting in the future. Methods: This was a retrospective, cross-sectional study performed at the University Hospital RWTH Aachen, Germany. We conducted a pragmatic systematic literature search in the PubMed database to identify RCTs on treatment interventions in COVID-19 patients in the first year of publications on the topic (March 2020-February 2021). We investigated the adherence of each publication to the CONSORT checklist and assessed the association between specific predictors and percentage adherence in an exploratory multivariable regression model. Results: We analyzed 127 RCTs and found that the median percentage adherence to the CONSORT checklist was 54.3% [IQR 38.9 to 65.7]. In the exploratory multivariable regression model, the impact factor (highest tertile of impact factor compared to lowest tertile ß = 21.77, 95% CI 13.89 to 29.66, p<0.001; middle tertile compared lowest tertile ß = 11.79, 95% CI 5.74 to 17.84, p<0.001)) and authors' referral to the CONSORT statement (ß = 9.29, 95% CI 2.98 to 15.60, p = 0.004) were associated with a higher percentage adherence to the CONSORT checklist. Conclusion: The reporting quality of RCTs on treatment interventions in COVID-19 patients during the first year of publications was poor. Measures to improve reporting quality are urgently needed. [ABSTRACT FROM AUTHOR]
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Poor reporting quality of randomized controlled trials comparing treatments of COVID-19–A retrospective cross-sectional study on the first year of publications.
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Autor/in / Beteiligte Person: | Grüßer, Linda ; Eißing, Charlotte ; Kowark, Ana ; Keszei, András P. ; Wallqvist, Julia ; Rossaint, Rolf ; Ziemann, Sebastian |
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Zeitschrift: | PLoS ONE, Jg. 18 (2023-10-16), Heft 10, S. 1-15 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0292860 |
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