Galectin-3's Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential.
In: Biomolecules (2218-273X), Jg. 13 (2023-10-01), Heft 10, S. 1500-1516
Online
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Zugriff:
Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). This review offers a comprehensive examination of its expression in PDAC, its interaction with various immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. Additionally, the prognostic significance of serum levels of Gal-3 is discussed, providing insights into its potential utilization as a biomarker. Critical analysis is also extended to the inhibitors of Gal-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments. The intricate nature of Gal-3's role in PDAC reveals a complex landscape that demands a nuanced understanding for potential therapeutic interventions and monitoring. [ABSTRACT FROM AUTHOR]
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Galectin-3's Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential.
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Autor/in / Beteiligte Person: | Dimitrijevic Stojanovic, Milica ; Stojanovic, Bojan ; Radosavljevic, Ivan ; Kovacevic, Vojin ; Jovanovic, Ivan ; Stojanovic, Bojana S. ; Prodanovic, Nikola ; Stankovic, Vesna ; Jocic, Miodrag ; Jovanovic, Marina |
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Zeitschrift: | Biomolecules (2218-273X), Jg. 13 (2023-10-01), Heft 10, S. 1500-1516 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 2218-273X (print) |
DOI: | 10.3390/biom13101500 |
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