肠内营养粉对老年稳定期COPD患者肺功能及 BODE指数的影响. (Chinese)

Objective To explore the effect of enteral nutrition powder on pulmonary function and BODE index in elderly patients with stable chronic obstructive pulmonary disease (COPD). Methods A total of 116 elderly stable COPD patients were selected and divided into the normal nutrition group (MNA>23.5 points, 24 cases), the malnutrition risk group (17.0 points ≤ MNA ≤ 23.5 points, 65 cases) and the malnutrition group (MNA<17.0 points, 27 cases) based on the MNA score. Ninety-two patients with malnutrition risk and malnutrition were randomly divided into the control group (routine treatment) and the experimental group (enteral nutrition powder was given on the basis of routine treatment). The experimental group was divided into two subgroups (MNA＜17.0 points，27 cases): group A (17.0 points ≤ MNA ≤ 23.5 points, 33 cases) and group B (MNA<17.0 points, 13 cases). At admission and 3 months after treatment, differences in body mass index (BMI), forced expiratory volume at 1 second (FEV 1 ), percentage of FEV 1 to predicted value (FEV 1 pred%), FEV 1 / FVC, 6-minute walking distance (6MWD), modified British Medical Research Council Respiratory Questionnaire (mMRC) and BODE index were compared between groups. Results Compared with the group with normal nutrition, the BMI, 6MWD and MNA scores were decreased in the malnutrition risk group, while the proportion of women in the malnutrition group, BMI, FEV 1 , FEV 1 pred%, 6MWD and MNA scores were decreased, and the mMRC and BODE index were increased (P＜0.05). BMI, FEV 1 and MNA scores were lower in the malnutrition group than those of the malnutrition risk group (P＜ 0.05). After 3-month treatment, BMI, FEV 1 , FEV 1 pred%, 6MWD and MNA scores were increased in the experimental group, while mMRC and BODE index decreased. The 6MWD and MNA scores were higher in the experimental group than those of the control group, while mMRC and BODE index were lower than those of the control group (P＜0.05). After 3 months of treatment, BMI, FEV 1 , 6MWD and MNA scores increased in the group A, while mMRC and BODE index decreased. BMI, FEV 1 , FEV 1 pred%, 6MWD and MNA scores increased in the group B, while BODE index decreased (P＜0.05). BMI, FEV 1 and MNA scores were lower in the group B than those of the group A, while mMRC and BODE index were higher than those of the group A (P＜0.05). The MNA score of COPD patients at admission was positively correlated with BMI, FEV 1 , FEV 1 pred%, FEV 1 /FVC and 6MWD, while negatively correlated with mMRC and BODE index (P＜0.05). Conclusion Enteral nutrition powder could improve lung function and BODE index in elderly stable malnutrition COPD patients. [ABSTRACT FROM AUTHOR]

目的 探讨肠内营养粉对老年稳定期慢性阻塞性肺疾病 (COPD)患者肺功能及BODE 指数的影响。方 法 选取116例老年稳定期COPD患者，按照微型营养评估 (MNA)评分分为营养正常组 (MNA＞23.5分，24例)、营养 不良风险组 (17.0分≤MNA≤23.5分，65例)和营养不良组 (MNA＜17.0分，27例)；92例营养不良风险及营养不良者随 机均分为对照组 (常规治疗)和试验组 (常规治疗基础上予肠内营养粉剂)；将试验组分为A组 (17.0分≤MNA≤23.5分， 33例)和B组 (MNA＜17.0分，13例)2个亚组。入院时及治疗3个月后，分别比较各组体质量指数 (BMI)、第1秒用力 呼气容积 (FEV 1 )、FEV 1 占预计值的百分比 (FEV 1 pred%)、FEV 1 /FVC、6 min步行距离 (6MWD)、改良版英国医学研究委 员会呼吸问卷 (mMRC)评分及BODE指数等指标差异。结果 与营养正常组比较，营养不良风险组BMI、6MWD和 MNA评分降低，营养不良组女性比例、BMI、FEV 1 、FEV 1 pred%、6MWD和MNA评分降低，mMRC评分和BODE指数均 升高 (P＜0.05)；营养不良组 BMI、FEV 1 和 MNA 评分低于营养不良风险组 (P＜0.05)。治疗 3 个月后，试验组 BMI、 FEV 1 、FEV 1 pred%、6MWD和MNA评分升高，mMRC评分和BODE指数降低，且试验组6MWD和MNA评分高于对照 组，mMRC评分和BODE指数低于对照组 (P＜0.05)。治疗3个月后，A组BMI、FEV 1 、6MWD和MNA评分升高，mMRC 评分和BODE指数降低；B组BMI、FEV 1 、FEV 1 pred%、6MWD和MNA评分升高，BODE指数降低 (P＜0.05)；B组BMI、 FEV 1 和 MNA 评分低于 A 组，mMRC 评分和 BODE 指数高于 A 组 (P＜0.05)。COPD 患者入院时 MNA 评分与 BMI、 FEV 1 、FEV 1 pred%、FEV 1 /FVC、6MWD呈正相关，与mMRC评分和BODE指数呈负相关 (P＜0.05)。结论 肠内营养粉 可改善老年稳定期营养不良COPD患者肺功能及BODE指数。 [ABSTRACT FROM AUTHOR]

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