Evaluation of the <superscript>177m</superscript>Lu-concentration in in-house produced <superscript>177</superscript>Lu-radiopharmaceuticals and commercially available Lutathera<superscript>®</superscript>.
In: EJNMMI Radiopharmacy & Chemistry, Jg. 8 (2023-11-06), Heft 1, S. 1-8
Online
academicJournal
Zugriff:
Background: 177 Lu-radiopharmaceuticals can contain the metastable impurity [ 177m Lu]lutetium with a physical half-life of 160.4 days, in varying concentrations depending on the route of production of the radionuclidic precursor [ 177 Lu]lutetium. Due to the long half-life of [ 177m Lu]lutetium, difficulties with waste disposal or sterility testing could arise. Here, we analyzed several 177 Lu-samples of different origins and suppliers regarding their 177m Lu-concentration. Results: All samples tested showed a 177m Lu-concentration in the range that was stated on the certificate of analysis from the supplier which is in accordance with the European Pharmacopoeia. Conclusions: Although all 177m Lu-concentrations were in accordance with the European Pharmacopoeia, we need to take into account the respective national legislation regarding radioactivity release limits. With regard to the German legislation, several probes for sterility testing in external laboratories could not be released for transport due to the concentration of [ 177m Lu]lutetium. Moreover, waste water tanks should specifically be monitored for 177m Lu-concentration, when e.g. Lutathera ® is administered in the clinic. [ABSTRACT FROM AUTHOR]
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Titel: |
Evaluation of the <superscript>177m</superscript>Lu-concentration in in-house produced <superscript>177</superscript>Lu-radiopharmaceuticals and commercially available Lutathera<superscript>®</superscript>.
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Autor/in / Beteiligte Person: | Balzer, Matthias ; Spiecker, Fleur ; Bluemel, Stephanie ; Amthauer, Holger ; Brenner, Winfried ; Spreckelmeyer, Sarah |
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Zeitschrift: | EJNMMI Radiopharmacy & Chemistry, Jg. 8 (2023-11-06), Heft 1, S. 1-8 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 2365-421X (print) |
DOI: | 10.1186/s41181-023-00222-2 |
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