Researchers from First Affiliated Hospital of Nanjing Medical University Detail Findings in Apoptosis (Zinc oxide nanoparticles-induced testis damage at single-cell resolution: Depletion of spermatogonia reservoir and disorder of Sertoli cell...).

A recent study conducted by researchers from the First Affiliated Hospital of Nanjing Medical University in China has examined the effects of zinc oxide nanoparticles (ZnO NPs) on testicular tissues at the single-cell level. The study found that ZnO NPs had deleterious effects on spermatogonia, Sertoli cells, and macrophages, leading to cell apoptosis and disruption of blood-testis barrier formation. The researchers identified two distinct maturation states of spermatogonia and observed reservoir exhaustion of undifferentiated spermatogonia due to ZnO NPs exposure. The study provides insights into the mechanisms of ZnO NPs-induced testis damage and may contribute to the development of biomarkers and therapeutics for this disorder. [Extracted from the article]

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