Reports from Sanford Burnham Prebys Medical Discovery Institute Advance Knowledge in Cytoplasmic and Nuclear Receptors (Insufficient Support for Retinoic Acid Receptor Control of Synaptic Plasticity Through a Non-genomic Mechanism).
In: Drug Week, 2023-11-17, S. 1922-1922
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Zugriff:
A recent study conducted at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla, California, examined the role of retinoic acid receptors (RARs) in controlling synaptic plasticity. While it is well-known that RARs function as nuclear receptors that regulate gene expression in response to retinoic acid, some studies have suggested that RAR-alpha (RARa) may also have non-genomic effects on synaptic plasticity. However, the researchers found insufficient evidence to support this hypothesis, as there have been no mutational studies demonstrating that RARa can bind to GluA1 mRNA to control protein levels in a non-genomic manner. Additionally, the absence of genetic studies removing the endogenous ligand retinoic acid makes it impossible to conclude that RARa and retinoic acid control synaptic plasticity through a non-genomic signaling mechanism. The study was supported by the NIH National Eye Institute. [Extracted from the article]
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Reports from Sanford Burnham Prebys Medical Discovery Institute Advance Knowledge in Cytoplasmic and Nuclear Receptors (Insufficient Support for Retinoic Acid Receptor Control of Synaptic Plasticity Through a Non-genomic Mechanism).
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Zeitschrift: | Drug Week, 2023-11-17, S. 1922-1922 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6440 (print) |
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