The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients.
In: BMC Research Notes, Jg. 16 (2023-11-18), Heft 1, S. 1-8
Online
academicJournal
Zugriff:
Introduction: Matrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. Materials and methods: A total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis. Results: The MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively. Conclusion: The MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11. [ABSTRACT FROM AUTHOR]
Copyright of BMC Research Notes is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients.
|
---|---|
Autor/in / Beteiligte Person: | Belachew, Esmael Besufikad ; Desta, Adey Feleke ; Deneke, Dinikisira Bekele ; Gebremariam, Tewodros Yalew ; Tefera, Dessalegn Abeje ; Atire, Fikadu Alemu ; Alemayehu, Dawit Hailu ; Seyoum, Tamirayehu ; Bauer, Marcus ; Girma, Selfu ; Sewasew, Dareskedar Tsehay ; Kantelhardt, Eva J. ; Tessema, Tesfaye Sisay ; Howe, Rawleigh |
Link: | |
Zeitschrift: | BMC Research Notes, Jg. 16 (2023-11-18), Heft 1, S. 1-8 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1756-0500 (print) |
DOI: | 10.1186/s13104-023-06518-5 |
Schlagwort: |
|
Sonstiges: |
|