National Chung Hsing University Researchers Release New Data on Hormone Replacement Therapy (Hyaluronic Acid Conjugated with 17b-Estradiol Effectively Alleviates Estropause-Induced Cognitive Deficits in Rats).

A recent study conducted by researchers at National Chung Hsing University in Taiwan explored the effects of hormone replacement therapy on cognitive deficits in rats. The researchers used a novel polymeric drug called hyaluronic acid-17b-estradiol conjugate (HA-E2) to deliver estradiol to the brain. The study found that HA-E2 treatment resulted in improvements in the cholinergic septo-hippocampal innervation system, synaptic transmission in hippocampal pyramidal neurons, and cognitive functions such as spatial learning and memory. These findings suggest that HA-E2 may be effective in preventing and improving estrogen-deficiency-induced cognitive impairment and Alzheimer's disease. [Extracted from the article]

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