Reports from Jinan University Describe Recent Advances in Diabetic Nephropathy (Astragalus polysaccharide promotes autophagy and alleviates diabetic nephropathy by targeting the lncRNA Gm41268/PRLR pathway).

A recent study conducted by researchers at Jinan University in Guangzhou, China, explored the effects of Astragalus polysaccharide (APS) on diabetic nephropathy (DN). APS is a bioactive component of the Chinese herb astragalus and has been shown to have protective effects on the kidney. The study found that APS treatment reduced urinary protein levels, improved glucose intolerance, and alleviated renal damage in mice with DN. APS also enhanced autophagy and reduced fibrosis in the kidneys. The researchers identified a novel long non-coding RNA (lncRNA), Gm41268, and its target gene, prolactin receptor (PRLR), as key factors in the therapeutic effect of APS on DN. This research contributes to the exploration of Chinese herbs as potential treatments for DN. [Extracted from the article]

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