ROS-generating nanoplatforms as selective and tunable therapeutic weapons against cancer.
In: Discover Nano, Jg. 18 (2023-12-11), Heft 1, S. 1-23
Online
academicJournal
Zugriff:
Reactive species refers to a group of chemicals, mainly reactive oxygen species (ROS) and reactive nitrogen species (RNS), that are naturally formed by cells as a byproduct of cell metabolism and regulated by various internal and external factors. Due to their highly chemical reactivity, ROS play a crucial role in physiological and pathological processes which is why studies on ROS regulation for disease treatment show attracted increasing interest. Notably, ROS are now studied as a powerful therapeutic weapon in ROS-regulating therapies such as ROS-based cytotoxic therapies mediated by ROS-increasing agents for cancer treatment. Thanks to the significant progress in nanotechnology, innovative nanoplatforms with ROS-regulating activities have been developed to look for effective ROS-related nanomedicines. In this review, studies on ROS-based cytotoxic therapies against cancer as photodynamic therapy (PDT), sonodynamic therapy (SDT), radiation therapy (RT) and chemodynamic therapy (CDT) are discussed, with a focus on the stimuli-responsive ROS-generating nanoplatforms developed for breaking the current therapeutic limits of ROS-based cytotoxic therapies. Finally, we suppose that our review on this developing field will be valuable for promoting the progress of ROS-based cytotoxic therapies not only in basic research but overall, in translational research and clinical application. [ABSTRACT FROM AUTHOR]
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ROS-generating nanoplatforms as selective and tunable therapeutic weapons against cancer.
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Autor/in / Beteiligte Person: | Foglietta, Federica ; Serpe, Loredana ; Canaparo, Roberto |
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Zeitschrift: | Discover Nano, Jg. 18 (2023-12-11), Heft 1, S. 1-23 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 2731-9229 (print) |
DOI: | 10.1186/s11671-023-03939-w |
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