Prognostic Factors Influencing Survival in Ovarian Cancer Patients: A 10-Year Retrospective Study.

Simple Summary: The prognosis of ovarian cancer patients is intricately shaped by a multitude of factors, and there exist several pivotal favorable prognostic factors that exert a discernible influence on survival. In this study, we analyzed factors influencing the survival of ovarian cancer patients in Cyprus. We examined data from 106 women with ovarian cancer and found that the FIGO stage, type of surgery, and performance status were significant factors associated with overall survival (OS). Progression-free survival (PFS) was influenced by FIGO stage and performance status. For patients with high-grade serous carcinoma, the performance status, FIGO stage, and type of surgery were initially considered prognostic factors, but in multivariate analysis, only performance status and FIGO stage remained statistically significant for OS. These findings contribute to our understanding of disease and could help improve treatment and patient outcomes. Objective: To analyze the factors associated with overall survival (OS) and progression-free survival (PFS) in patients with ovarian cancer in Cyprus. Methods: We retrospectively analyzed data from patients with histologically confirmed epithelial ovarian cancer (EOC) and primary peritoneal cancer (PPC). Results: A total of 106 women diagnosed with ovarian cancer were included, with a median age at diagnosis of 58 years. The Kaplan–Meier survival analysis showed a median OS of 41 months (95% C.I = 36.9, 45.1), and the FIGO stage (p < 0.001), type of surgery (p < 0.001) and performance status (p < 0.001) were identified as statistically significant prognostic factors for OS. PFS analysis revealed the FIGO stage (p = 0.006) and the performance status (p < 0.001) as significant prognostic factors. Additionally, a Cox regression analysis for median OS was performed for patients with high-grade serous carcinoma, identifying the performance status, FIGO stage, and type of surgery as prognostic factors in univariate analysis. However, in the subsequent multivariate analysis, the performance status and the FIGO stage were confirmed to be the only statistically significant prognostic factors for OS (p < 0.05). Conclusions: This study confirms that the FIGO stage, performance status, and surgery type were considered as prognostic factors for OS in ovarian cancer. [ABSTRACT FROM AUTHOR]

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