Evaluation of the Local Control Rate and Late Toxicity of High-Dose-Rate Interstitial Brachytherapy in Tongue Squamous Cell Carcinoma.
In: Journal of Iranian Medical Council (JIMC), Jg. 7 (2024), Heft 1, S. 168-179
academicJournal
Zugriff:
Background: Tongue Squamous Cell Carcinoma (TSCC) is one of the most consequential oral Squamous Cell Carcinomas (SCC) worldwide. Methods: This retrospective cross-sectional study was conducted on 29 TSCC patients treated with High Dose Rate Brachytherapy (HDR-BT) with or without External Beam Radiotherapy (EBRT) between 2017-2020. Patients without distant metastasis at the time of treatment and at least one year after completion of brachytherapy were included. Results: One-year Overall Survival (OS), Disease-Free Survival (DFS), and Local Control Rate (LCR) were 82.8, 79.3, and 100%, respectively. 6 patients (20.7%) had distant metastasis, of which 5 (17.2%) died. Local recurrence was not observed in any patients, and only one (3.4%) regional recurrence occurred. The most common late toxicity of HDR-BT was dry mouth (79.2%) and dysarthria (66.7%). There were no severe and life-threatening complications (grades 3 and 4) during one year. Also, 79.2% of the patients had good functional performance. One-year OS, the significant difference between the two groups of HDR-BT with and without EBRT (p=0.055). Conclusion: Our findings indicated that the HDR-BT increases the OS of TSCC patients more than EBRT without developing grade 3-4 AEs and metastasis. We showed that the mean 3.2 ±0.7 Gy of HDR-BT has more OS compared to EBRT. [ABSTRACT FROM AUTHOR]
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Titel: |
Evaluation of the Local Control Rate and Late Toxicity of High-Dose-Rate Interstitial Brachytherapy in Tongue Squamous Cell Carcinoma.
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Autor/in / Beteiligte Person: | Amiri, Iman ; Feli, Maryam ; Bagheri, Ali ; Shahbazian, Hojattollah ; Mohammadian, Fatemeh |
Zeitschrift: | Journal of Iranian Medical Council (JIMC), Jg. 7 (2024), Heft 1, S. 168-179 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2645-338X (print) |
DOI: | 10.18502/jimc.v7i1.14224 |
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