Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice.
In: TB & Outbreaks Week, 2024-01-09, S. 1821-1821
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Zugriff:
This article discusses a study that investigated the genetic basis of pulmonary tuberculosis (TB) using Diversity Outbred mice. The researchers identified five new loci on mouse chromosomes 1, 2, 4, and 16, as well as three previously identified loci on chromosomes 3 and 17, that are associated with responses to Mycobacterium tuberculosis. Using a machine learning strategy, the researchers narrowed down the list of candidate genes in these loci to 11, all of which have roles in infection, inflammation, cell migration, extracellular matrix remodeling, or intracellular signaling. This study demonstrates the potential of using Diversity Outbred mice to identify new genetic regulators of granuloma necrosis and acute inflammation in pulmonary TB. [Extracted from the article]
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Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice.
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Zeitschrift: | TB & Outbreaks Week, 2024-01-09, S. 1821-1821 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6432 (print) |
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