Researchers at Nagasaki University Graduate School of Biomedical Sciences Publish New Study Findings on Apoptosis (Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast...).

A new study conducted by researchers at Nagasaki University Graduate School of Biomedical Sciences explores the role of Bcl2l1 (Bcl-XL) in osteoblasts and bone homeostasis. The study found that the deficiency of Bcl2l1 in osteoblasts led to a reduction in trabecular bone due to enhanced osteoclastogenesis, likely through osteoblast apoptosis. The researchers generated osteoblast-specific Bcl2l1-deficient mice and observed lower trabecular bone volume and trabecular number in these mice compared to control mice. The study suggests that Bcl2l1 may inhibit bone resorption by preventing osteoblast apoptosis. [Extracted from the article]

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