Researcher from Duke University School of Medicine Reports Recent Findings in Alzheimer Disease (A Continuous Extension of Gene Set Enrichment Analysis Using the Likelihood Ratio Test Statistics Identifies Vascular Endothelial Growth Factor as...).
In: Genomics & Genetics Weekly, 2024-01-19, S. 670-670
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A recent study conducted by researchers from Duke University School of Medicine in Durham, North Carolina, aimed to identify molecular pathways associated with Alzheimer's disease (AD) biomarkers and cognitive status. The study utilized a pathway-based statistical approach and analyzed three phenotypes (amyloid-b, tau, cognition) in 634 subjects. The researchers identified 14 pathways associated with amyloid-b, 5 associated with tau, and 174 associated with cognition. Notably, the vascular endothelial growth factor receptor binding (VEGF-RB) pathway exhibited associations with all three phenotypes, and ITGA5 was found to mediate the relationship between cognitive scores and pathological biomarkers. This study provides insights into the biological mechanisms underlying AD and highlights potential therapeutic targets. [Extracted from the article]
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Researcher from Duke University School of Medicine Reports Recent Findings in Alzheimer Disease (A Continuous Extension of Gene Set Enrichment Analysis Using the Likelihood Ratio Test Statistics Identifies Vascular Endothelial Growth Factor as...).
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Zeitschrift: | Genomics & Genetics Weekly, 2024-01-19, S. 670-670 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6467 (print) |
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