Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice.
In: Health & Medicine Week, 2024-01-26, S. 1179-1179
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Zugriff:
Researchers at the Broad Institute of MIT and Harvard have developed a new delivery system for prime editing, a form of gene editing that can correct disease-causing genetic mutations. The researchers engineered virus-like particles (eVLPs) to deliver prime editors to cells in mice, achieving a high editing efficiency. They successfully corrected disease-causing mutations in the eyes of mice with genetic blindness, partially restoring their vision. The researchers also delivered prime editors to the mouse brain without detecting any off-target editing. This study represents the first time that therapeutic prime editing has been achieved in an animal using protein-RNA complexes. [Extracted from the article]
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Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice.
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Zeitschrift: | Health & Medicine Week, 2024-01-26, S. 1179-1179 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6459 (print) |
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