The Parkinson's Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress (Updated January 17, 2024).
In: Health & Medicine Week, 2024-02-02, S. 1629-1629
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Zugriff:
A preprint abstract from biorxiv.org discusses the cooperation between multiple genes linked to Parkinson's Disease. The researchers generated cell lines that express either wild-type or a mutant form of the retromer component VPS35 (D620N), which is associated with Parkinson's Disease. They found that the mutant form of VPS35 compromises its association with the WASH complex but does not affect WASH recruitment to endosomes or the distribution of lysosomal receptors. The study also shows that the mutant form of VPS35 enhances the activity of the Parkinson's associated kinase LRRK2 and amplifies its response to endolysosomal stress. The research has not yet undergone peer review. [Extracted from the article]
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The Parkinson's Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress (Updated January 17, 2024).
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Zeitschrift: | Health & Medicine Week, 2024-02-02, S. 1629-1629 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6459 (print) |
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