Is There a Relationship between Insulin Resistance and Eosinophil, Inflammatory Parameters Neutrophil to lymphocyte ratio, C-Reactive Protein Values?

Aim: The relationship between insulin resistance and inflammation and atopy is a matter of curiosity and various studies have been conducted. Study results show differences. We aimed to evaluate the relationship between insulin resistance and inflammation and atopy using C-Reactive Protein (CRP) and Neutrophil to lymphocyte ratio (NLR) as eosinophils and inflammatory indices and to determine whether the low-cost hemogram can be used as a reliable marker. Material and Method: Between May 2022 and November 2023, 1566 children admitted to the Pediatrics outpatient clinics of İzmir Bakırçay University Çiğli Training and Research Hospital were retrospectively screened. A total of 349 pediatric patients without any known chronic disease and with complete blood count, CRP and HOMA-IR levels were retrospectively included in the study. Results: Individuals with HOMA-IR<2.5 were considered as control group and those with HOMA-IR=2.5 were considered as children with insulin resistance. As a result of Mann-Whitney-U test performed according to HOMA-IR groups, age and NLR parameters were found to be higher in the group with insulin resistance. This result was statistically significant (p<0.05). The results were not significant in eosinophil (p=0.324) and CRP (p=0.352) parameters. Conclusion: NLR value may be a credible predictive marker of insulin resistance. Inexpensive and simple complete blood count measurement may help in the early diagnosis of Type 2 DM and in the design of treatments. In addition, due to the increasing risk of insulin resistance with age, education on conscious nutrition can be given in schools during adolescence. [ABSTRACT FROM AUTHOR]

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