Covid-19-associated pulmonary aspergillosis in mechanically ventilated patients: incidence and outcome in a French multicenter observational cohort (APICOVID).
In: Annals of Intensive Care, Jg. 14 (2024-01-29), S. 1-9
Online
academicJournal
Zugriff:
Background: Recent studies identified coronavirus disease 2019 (COVID-19) as a risk factor for invasive pulmonary aspergillosis (IPA) but produced conflicting data on IPA incidence and impact on patient outcomes. We aimed to determine the incidence and outcomes of COVID-19-associated pulmonary aspergillosis (CAPA) in mechanically ventilated patients. Methods: We performed a multicenter retrospective observational cohort study in consecutive adults admitted to 15 French intensive care units (ICUs) in 2020 for COVID-19 requiring mechanical ventilation. CAPA was diagnosed and graded according to 2020 ECMM/ISHAM consensus criteria. The primary objective was to determine the incidence of proven/probable CAPA, and the secondary objectives were to identify risk factors for proven/probable CAPA and to assess associations between proven/probable CAPA and patient outcomes. Results: The 708 included patients (522 [73.7%] men) had a mean age of 65.2 ± 10.8 years, a median mechanical ventilation duration of 15.0 [8.0–27.0] days, and a day-90 mortality rate of 28.5%. Underlying immunosuppression was present in 113 (16.0%) patients. Corticosteroids were used in 348 (63.1%) patients. Criteria for probable CAPA were met by 18 (2.5%) patients; no patient had histologically proven CAPA. Older age was the only factor significantly associated with probable CAPA (hazard ratio [HR], 1.04; 95% CI 1.00–1.09; P = 0.04). Probable CAPA was associated with significantly higher day-90 mortality (HR, 2.07; 95% CI 1.32–3.25; P = 0.001) but not with longer mechanical ventilation or ICU length of stay. Conclusion: Probable CAPA is a rare but serious complication of severe COVID-19 requiring mechanical ventilation and is associated with higher day-90 mortality. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Intensive Care is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Covid-19-associated pulmonary aspergillosis in mechanically ventilated patients: incidence and outcome in a French multicenter observational cohort (APICOVID).
|
---|---|
Autor/in / Beteiligte Person: | Desmedt, Luc ; Raymond, Matthieu ; Le Thuaut, Aurélie ; Asfar, Pierre ; Darreau, Cédric ; Reizine, Florian ; Colin, Gwenhaël ; Auchabie, Johann ; Lorber, Julien ; La Combe, Béatrice ; Kergoat, Pierre ; Hourmant, Baptiste ; Delbove, Agathe ; Frérou, Aurélien ; Morin, Jean ; Ergreteau, Pierre Yves ; Seguin, Philippe ; Martin, Maëlle ; Reignier, Jean ; Lascarrou, Jean-Baptiste |
Link: | |
Zeitschrift: | Annals of Intensive Care, Jg. 14 (2024-01-29), S. 1-9 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2110-5820 (print) |
DOI: | 10.1186/s13613-023-01229-3 |
Schlagwort: |
|
Sonstiges: |
|