Data from University of Colorado School of Medicine Advance Knowledge in Kinase Inhibitors (The Efficacy and Safety of Treating Acquired MET Resistance Through Combinations of Parent and MET Tyrosine Kinase Inhibitors in Patients With...).
In: Pain & Central Nervous System Week, 2024-03-01, S. 255-255
serialPeriodical
Zugriff:
A study conducted by the University of Colorado School of Medicine explores the efficacy and safety of combining MET tyrosine kinase inhibitors (TKIs) with parent TKIs to target acquired MET resistance in patients with metastatic oncogene-driven non-small cell lung cancer (NSCLC). The study involved 83 patients who were divided into two cohorts: the MET cohort, which received a MET TKI in addition to their parent TKI, and the chemotherapy cohort, which received a platinum-pemetrexed in addition to their parent TKI. The study found that the MET cohort had a higher objective response rate compared to the chemotherapy cohort, but there was no significant difference in progression-free survival or overall survival between the two cohorts. The study also identified molecular patterns on progression with dual parent and MET TKI combinations. The researchers concluded that combining MET TKIs with parent TKIs is effective in treating acquired MET resistance. [Extracted from the article]
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Data from University of Colorado School of Medicine Advance Knowledge in Kinase Inhibitors (The Efficacy and Safety of Treating Acquired MET Resistance Through Combinations of Parent and MET Tyrosine Kinase Inhibitors in Patients With...).
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Zeitschrift: | Pain & Central Nervous System Week, 2024-03-01, S. 255-255 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6394 (print) |
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