The Role of the Nuclear Factor-Kappa B (NF-κB) Pathway in SARS-CoV-2 Infection.
In: Pathogens, Jg. 13 (2024-02-01), Heft 2, S. 164-187
Online
academicJournal
Zugriff:
COVID-19 is a global health threat caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with a significant increase in morbidity and mortality. The present review discusses nuclear factor-kappa B (NF-κB) activation and its potential therapeutical role in treating COVID-19. COVID-19 pathogenesis, the major NF-κB pathways, and the involvement of NF-κB in SARS-CoV-2 have been detailed. Specifically, NF-κB activation and its impact on managing COVID-19 has been discussed. As a central player in the immune and inflammatory responses, modulating NF-κB activation could offer a strategic avenue for managing SARS-CoV-2 infection. Understanding the NF-κB pathway's role could aid in developing treatments against SARS-CoV-2. Further investigations into the intricacies of NF-κB activation are required to reveal effective therapeutic strategies for managing and combating the SARS-CoV-2 infection and COVID-19. [ABSTRACT FROM AUTHOR]
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Titel: |
The Role of the Nuclear Factor-Kappa B (NF-κB) Pathway in SARS-CoV-2 Infection.
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Autor/in / Beteiligte Person: | Kesika, Periyanaina ; Thangaleela, Subramanian ; Sisubalan, Natarajan ; Radha, Arumugam ; Sivamaruthi, Bhagavathi Sundaram ; Chaiyasut, Chaiyavat |
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Zeitschrift: | Pathogens, Jg. 13 (2024-02-01), Heft 2, S. 164-187 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2076-0817 (print) |
DOI: | 10.3390/pathogens13020164 |
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