HOPE in Action Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes.

This article discusses a clinical trial conducted by Johns Hopkins University, NCT06263426, which focuses on understanding rejection in transplant recipients with HIV who receive kidneys from donors with or without HIV. The trial will track various outcomes such as participant survival, graft survival, type and severity of graft rejection, and incidence of HIV viremia and opportunistic infections. This research is significant because it explores the possibility of using organs from donors with HIV, which was not previously allowed before the HOPE Act in 2013. Previous studies have shown successful transplants and HIV control in people with HIV who received organs from HIV-positive donors. The study is currently in the recruitment phase and aims to enroll 200 participants, with an estimated completion date of September 2029. It is being conducted by Johns Hopkins University in collaboration with the National Institute of Allergy and Infectious Diseases. [Extracted from the article]

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